AN APPROACH TO TIrE PROBLEM OF INTRAVENOUS FOREIGN PROTEIN THERAPY

The antigenicity of foreign protein solutions complicates their employment either as plasma substitutes, or as nutritive agents. Recently interest has been aroused in the possibility of doing away with antigenicity, while retaining the great molecular weight of the protein. The present paper deals with the effects of light energy in the reduction of the antigenicity of horse serum, thus rendering it tolerable to guinea pigs. The problem of sensitivity as a bar to the intravenous injection of foreign proteins is discussed incidentally, and the methods currently employed to reduce antigenicity are considered.